Purified anti-human CD47 Antibody - CD47 also known as Rh-associated protein, gp42, integrin-associated protein (IAP), and neurophilin, is a 42-52 kD member of the immunoglobulin superfamily containing a five-pass transmembrane attachment.

Anti-CD47 Antibody Products. Anti-CD47 antibodies are offered by a number of suppliers. This target gene encodes the protein 'CD47 molecule' in humans and may also be known as IAP, MER6, OA3, leukocyte surface antigen CD47, and CD47 antigen (Rh-related antigen, integrin-associated signal transducer). Structurally, the protein is reported to be

Anti-CD47 antibody produced in rabbit Prestige Antibodies ® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution Synonym: Anti-IAP, Anti-MER6, Anti-OA3 Human Protein Atlas Number HPA044659 Human Protein Atlas - View RNA & protein expression data of this target Anti-CD47 antibody–mediated phagocytosis of cancer by macrophages primes an effective antitumor T-cell response Diane Tsenga,b,1, Jens-Peter Volkmer a,b, Stephen B. Willingham , Humberto Contreras-Trujilloa,b, 2021-04-22 · Clinical trials are research studies that involve people. The clinical trials on this list are studying Anti-CD47 Monoclonal Antibody Hu5F9-G4. All trials on the list are supported by NCI. NCI’s basic information about clinical trials explains the types and phases of trials and how they are CD47 Binding to SIRP alpha /CD172a Blocked By Mouse CD47 Antibody. In a functional ELISA, 0.08-0.8 µg/mL of this antibody (green line) will block 50% of the binding of 0.25 µg/mL of Recombinant Mouse CD47 Fc Chimera (orange line, Catalog # 1866-CD ) to immobilized Recombinant Mouse SIRPa/CD172a Fc Chimera (Catalog # 7154-SA ) coated at 1 µg/mL (100 µL/well). Because CD47 is widely expressed in the immune system, the use of anti-CD47 therapeutic mAbs alone is not efficient. In some extreme cases, this inability may cause unfavorable pharmacokinetic characteristics or chronic toxicity, endangering patients’ systems, To overcome this, we propose an anti-CD47/CD19 bispecific antibody to tamper the Blocking CD47 using SIRPa-Fc or anti-CD47 antibodies (Ab) has emerged as a promising strategy to neutralize CD47 and promote tumor eradication. However, targeting CD47 led to significant anemia and thrombocytopenia in both pre-clinical studies and phase I trials as CD47 is also expressed on normal red blood cells (RBCs) and platelets.

T cell expression of CD47 can mediate activation or apoptosis (in the presence of high levels of thrombospondin). Recently stimulation of CD47 by monoclonal antibody has been shown to induce CD4+CD25- suppressive activity also increasing expression of Foxp3. Here, we report the identification of CD47, a protein that inhibits phagocytosis, as an antibody target in standard and high-risk ALL. CD47 was found to be more highly expressed on a subset of human ALL patient samples compared with normal cell counterparts and to be an independent predictor of survival and disease refractoriness in several ALL patient cohorts. CD47 also known as Rh-associated protein, gp42, integrin-associated protein (IAP), and neurophilin, is a 42-52 kD member of the immunoglobulin superfamily containing a five-pass transmembrane attachment. Two splice variants have been described in the cytoplasmic tail, the shorter form is expresse Purified anti-human CD47 Antibody - CD47 also known as Rh-associated protein, gp42, integrin-associated protein (IAP), and neurophilin, is a 42-52 kD member of the immunoglobulin superfamily containing a five-pass transmembrane attachment.

As such, CD47 is the focus of intense immuno-oncology drug development efforts.

The MIAP301 monoclonal antibody reacts with mouse CD47 otherwise known as integrin-associated protein (IAP). CD47 is an approximately 50 kDa glycosylated five transmembrane protein that is ubiquitously expressed by both hematopoietic cells such as T and B lymphocytes, monocytes, platelets and erythrocytes and non-hematopoietic cells.

Structurally, the protein is reported to be Antigen identified by monoclonal antibody 1D8 antibody; Antigenic surface determinant protein OA3 antibody; CD 47 antibody; CD47 antibody; CD47 antigen (Rh-related antigen, integrin-associated signal transducer) antibody; CD47 antigen antibody; CD47 glycoprotein antibody; CD47 molecule antibody; CD47_HUMAN antibody; IAP antibody; Integrin Associated Protein antibody Antibody information for antibodies HPA044659 and CAB016055 used in analysis of ENSG00000196776 / CD47 (IAP, MER6, OA3) The B6H12 monoclonal antibody reacts with human CD47 otherwise known as integrin-associated protein (IAP), and neurophilin. CD47 is an approximately 50 kDa glycosylated five transmembrane protein that is ubiquitously expressed by both hematopoietic cells such as T and B lymphocytes, monocytes, platelets and erythrocytes and non-hematopoietic cells.

View Mouse CD47 Antibody (MAB18661) validated in Mouse. Additional non- catalog clones available.

Antibody information for antibodies HPA044659 and CAB016055 used in analysis of ENSG00000196776 / CD47 (IAP, MER6, OA3) ZF1 is comparable with humanized anti-CD47 blocking antibody B6H12 in terms of high specificity and affinity for CD47; ZF1 can even induce stronger phagocytosis of leukemic cancer cells by macrophages than B6H12 in vitro. 18 In the same year, Gizem 19 reported that the diminishing interaction of CD47-SIRPα can enhance the killing of macrophages on tumor cells. Anti-CD47 antibodies are offered by a number of suppliers. This target gene encodes the protein 'CD47 molecule' in humans and may also be known as IAP, MER6, OA3, leukocyte surface antigen CD47, and CD47 antigen (Rh-related antigen, integrin-associated signal transducer). The B6H12 monoclonal antibody reacts with human CD47 otherwise known as integrin-associated protein (IAP), and neurophilin. CD47 is an approximately 50 kDa glycosylated five transmembrane protein that is ubiquitously expressed by both hematopoietic cells such as T and B lymphocytes, monocytes, platelets and erythrocytes and non-hematopoietic cells. Epitope binning of anti-CD47 antibodies.

Anti-CD47 antibodies are offered by a number of suppliers. This target gene encodes the protein 'CD47 molecule' in humans and may also be known as IAP, MER6, OA3, leukocyte surface antigen CD47, and CD47 antigen (Rh-related antigen, integrin-associated signal transducer). Structurally, the protein is reported to be 35.2 kilodaltons in mass. Rabbit recombinant monoclonal CD47 antibody [SP279]. Validated in IHC and tested in Human. Cited in 1 publication(s).
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2010-09-03 Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu72 of human CD47 protein.

The clinical trials on this list are studying Anti-CD47 Monoclonal Antibody Hu5F9-G4. All trials on the list are supported by NCI. NCI’s basic information about clinical trials explains the types and phases of trials and how they are CD47 Binding to SIRP alpha /CD172a Blocked By Mouse CD47 Antibody.
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The B6H12 monoclonal antibody reacts with human CD47 otherwise known as integrin-associated protein (IAP), and neurophilin. CD47 is an approximately 50 kDa glycosylated five transmembrane protein that is ubiquitously expressed by both hematopoietic cells such as T and B lymphocytes, monocytes, platelets and erythrocytes and non-hematopoietic cells.

23, EP13849989.2, EP2925782. ANTI-CD47 ANTIBODIES AND METHODS OF USE THEREOF. A61K39/00; C07K16/28; C07K16/46. NovImmune SA. 2013-12- 2013-11-15. 132, EP13849989.2, EP2925782. ANTI-CD47 ANTIBODIES AND METHODS OF USE THEREOF. A61K39/00; C07K16/28; C07K16/46.

NEDD8-activating enzyme inhibitors, isocitrate dehydrogenase 1/2 inhibitors, BCL-2 inhibitors, and CD47 antibodies—are being investigated to improve care

HÄNVISNINGSTERMER. AC133 1 Antigen; AC133-1 Antigen; Antigen, AC133-1; Antigen, CD133 "Just days ago, AbbVie wagered $200 million in cash to license global rights to an anti-CD47 antibody from China's I-Mab, which concurrently raised a Cd47, CD47 antigen (Rh-related antigen, integrin-associated signal transducer) Lyar, Ly1 antibody reactive clone, 1402, 51.57, 34.95, 48.81, 45.11, 4778.

Värd, Rabbit.